Skip to content
Home > Anti-GBM antibodies – possible false positives

Anti-GBM antibodies – possible false positives

[featured_image]
  • Version
  • Download 1342
  • File Size 582.22 KB
  • File Count 1
  • Create Date 23/06/2023
  • Last Updated 23/06/2023

Anti-GBM antibodies - possible false positives

We have received a field safety notice from our anti-GBM antibody assay manufacturer (Phadia), stating that their assay design 'may contribute to the identification of some false positive GBM results for specific samples containing anti-BSA antibodies'. This affects both weak and strong positive anti-GBM antibody results.

As a result we are now routinely sending all first time positive anti-GBM antibodies (results >10 U/mL) to Tayside Immunology laboratory for confirmation by immunoblot assay. Tayside have confirmed that they perform this immunoblot assay weekly.

We will continue to phone all first time positive anti-GBM antibody results to the requesting clinician/ward/external laboratory.

Further details are available within the attached letter available for download below. Please contact us if you have any further questions.

Attached Files

1 file
GBM Service User Letter June 2023.pdf
582.22 KB